Explore fundamental proprieties of neuronal circuits in Neurofluidics™ devices. Dissociated neuronal cultures can be used to investigate neuronal networks kinetics, molecular transport or electrophysiological functional recordings.
Evaluate a compound’s effect on the dynamics of axonal growth with or without injury. The gravity driven flow successfully demonstrates the potential of this technique for in vitro neuronal circuit development and its regeneration post-neuronal injury.
Neurofluidics™ devices are ideally suited for high-resolution axonal transport studies. The microgrooves technology enables a fluid isolation between compartments to facilitate the measurement of transport velocity on a large number of axons simultaneously.
Neurofluidics™ approach enables continuous electrophysiological recordings providing data to investigate a compound’s impact on functional activity and recovery, synapse formation or network dynamics.
Replicate the neuroinflammation process in Neurofluidics™ devices and evaluate microglial localization post injury. By using large microchannels between chambers, gradients of injury molecules can provide chemiotaxis routes glial cells, providing fast access to neuroprotection effects and kinetics of a compound.
Our Basal Ganglia loop-on-chip provides a unique in vitro solution to study different mechanisms of prion-like spreading molecules. The Deposition Chamber technology maintains the cell density ratios and directionality pattern of their in vivo counterparts .