The Asymetric tri-compartment device allows the reconstitution of a neural network between two neural populations connected through a fluidly isolated synaptic chamber. Thanks to the asymmetry of the connecting microchannels, axons from one population connect to dendrites from the other ,with a high probability,only in the middle compartment. The use of mutliplexed microchannels offer also the possibility to study subcellular trafficking while altering synapses. Coupled to MEA, the device can be used to monitor electrophysiological impact of a synaptic effect of a compound when applying in the synaptic chamber only. Alternatively, by seeding cells in the middle compartment when a neural network is matured, interactions between several type of cells and synapses can be monitored.
Applicable diseases: Alzheimer, Parkinson, …
Readouts: presynaptic dynamics, synaptic structures and transmission, postsynaptic traffic and signaling.

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