Neurofluidic devices are ideally suited for high-resolution axonal transport studies. The microchannel technology enables a fluidic isolation between compartments. The measurement of retrograde transport kinetics is done simultaneously on a large number of axons.
The Asymetric Tri-Compartment device is perfectly suited to conduct high-resolution vesicular transport studies. Co-culture of different neuronal types allows the creation of synaptic compartment to reproduce physiological conditions.
Disease applications : neuro-muscular junction disorders (ALS), Huntington Chorea, Molecular mechanisms involved in neural troubles, Prion-like diseases
Readouts: IF, Cell viability, Molecular propagation, Calcium imaging, Electrophysiology…