Time to reproduce real brain circuits-on-chip
Our brain-on-chip devices integrate different technologies into the same chip:
- 3D-Deposition Chambers: Cells are seeded and cultured into sized chambers in which density and homogeneity are controlled in a reproducible manner. Deposition chamber can accept from 1000 to 1 million dissociated cells, explants or organoids.
- Microchannels: Chambers are connected by micrometer channels in which only neurites can grow in a uni- or bidirectional way. Chambers are fluidly isolated while maintaining axonal transport.
- Membrane technology: Polystyrene porous membranes can be integrated in deposition chambers to create compartmentalized and connected barriers.
Our devices are designed for long term co-cultures (up to 3 months), thanks to our choice of materials composed of polydimethylsiloxane (PDMS) and polycarbonate (PC).
Our chips reproduce the physiological behavior of any organs. Multi organs interactions, such as gut-brain axis, can also be mimicked when integrating all our technologies within one chip.